4ptool.be

The 4P Tool is designed to assist you in gaining a better insight into your personal Parkinson patient population. For general information or help: mail to [email protected] Prof. A. Jeanjean (Cliniques Universitaires Saint Luc Bruxelles) and Dr. A. Flamez (UZ Brussel, Vrije Universiteit Brussel) are acknowledged for their profound expert advise on the content of this program. The 4P Tool is provided for your convenience, without any warranties, representations or guarantees of any kind. Concept and development by Ismar Healthcare: www.ismar.com Supported by Boehringer Ingelheim Belgium: www.boehringer-ingelheim.be Intel® Pentium® III 1GHz or faster processor, 512MB of RAM Recommended: Pentium 4 2GHz or faster, 1GB RAM Windows Vista® Home Premium, Business, Ultimate, or Enterprise including 64 bit editions, Windows Vista SP1, Windows XP Tablet PC Edition SP2 and SP3, Windows XP SP2 and SP3, Windows 2000 SP4, Windows 2003 Server Intel Core™ Duo 1.83GHz or faster processor; PowerPC® G4 1GHz or faster processor Mac OS X 10.4.11 or Mac OS X 10.5.4 and 10.5.5 Intel® Pentium® III 1GHz or faster processor, 512MB of RAM Recommended: Pentium 4 2GHz or faster, 1GB RAM Fedora 8, Ubuntu 7.10, openSUSE 10.3 The 4P Tool is an AIR application: Administrative access is required to install the runtime Adobe AIR.
When installing the 4P Tool, antivirus or security software may report the attempt to connect to an Internet Service. You should allow this connection to install the 4P Tool. The installation of the 4P Tool consists of 3 subsequent steps:step 1 : installation/update of Flash Player 10 (if not installed yet)step 2 : installation/update of runtime Adobe Air (if not installed yet)step 3 : installation/update of 4P Tool Make sure you are connected to the internet Go to www.4ptool.be

If the Flash Player 10 has not yet been installed : → click the ‘Get Adobe Flash Player' button → click the ‘Agree and install now' button on the Adobe website (http://get.adobe.com/flashplayer/) → follow the on-screen instructions to install the Adobe Flash Player Return to www.4ptool.be and continue with the following steps Click the ‘Install now' button on the installation batch If Adobe Air runtime has not been installed on your computer yet, you will be requested to download and install this runtime. Click the ‘Yes' button to start the installation and follow the on-screen instructions. In case of problems with the installation of the Adobe Air runtime:go to http://get.adobe.com/air/ and click the ‘Download now' button The 4P Tool will be installed automatically. Click the ‘Open' button in the window asking ‘Would you like to open or save this file ? 'If you do not want to open the 4P Tool immediately, click the ‘Save' button instead of the ‘Open' button. You will be asked to indicate the location where you want to save the installer package. Click the 4P Tool folder (installer package) in this location to proceed with the installation as described below.
Click the ‘Install' button when asked ‘Are you sure you want to install this application to your computer?' In the next window, you will be asked: → if a shortcut icon needs to be added to your desktop (optional) → where you want to install the 4P Tool : click the ‘folder icon' to change the standard location Then click the ‘Continue' button The 4P Tool will be installed and opened automatically Log in with your unique login name and password Internet connection is required to:• install the 4P Tool update the 4P Tool: when connected to the internet, the program automatically checks for online software updates; your are advised to backup your local data before installing any new version, and to restore these data to the new version change your password or ask for a new password: upon submission of your request, your new password is automatically sent by e-mail activate your new password: the first time you log on after asking for a new password, your password will be automatically activated if you are connected to the internet; if you are not connected to the internet, you will be prompted to use your old password No internet connection is required to: • enter/modify patient data analyse/export patient data create backup/restore backup Secured access:• your 4P identification code consists of your e-mail address and a unique login name → remember your e-mail address and your login name; if you want to change the e-mail address linked to your login name, mail to [email protected] your login name and password are sent by e-mail; you are advised to change this password immediately → remember your new password your personal database is stored on your local computer; it is linked with your login name and your password → your login name and your password are absolutely required to access your database (this cannot be overruled by an administrator) encryption of database: decoding your personal database or your backup file is only possible through the 4P Tool; your personal login name and password are required for this action → your backup file cannot be used to analyse or consult data → if your password is changed, immediately make a new backup file in order to have it encrypted with your new No data storage on remote server:• The current 4P Tool release authorises one-way software exchange via the internet for registered users, i.e. it allows for downloading the tool, setting up an encrypted database on your local computer and sending notifications when updated versions are available (push); no data are pulled from your personal database.
Data are stored on your personal computer in an encrypted database → no data synchronisation: your database is only available on this computer; to use the 4P Tool on different computers, the database requires backup and restoration from one computer to another (create backup/restore backup) → no automatic backup: you are strongly advised to regularly create a backup file and to save it on an external memory (create backup) → no data sharing: to share data, you have to export data (export to Excel) and send the file by e-mail → install 4P updates: to avoid any version incompatibility, you are advised to backup your local data before installing any new version (create backup), and to restore these data to the new version (restore backup) LOGIN

To log on for the 4P Tool:
•
fill in your login name (not case-sensitive) fill in the correct password (case-sensitive) click the ‘Login' button you will be automatically redirected to the home page In case of problems with login: mail to [email protected] CHANGE PASSWORD
To change your password:• make sure you are connected to the internet click the ‘Change password' button in the login screen fill in your login name (not case-sensitive) fill in your old password (case-sensitive) fill in your new password (case-sensitive) confirm your new password (case-sensitive) click the ‘Confirm' button to change your password; you will be automatically redirected to the home page click the ‘Cancel' button to return to the login screen for login with your old password New password requirements:• at least one lowercase letter at least one uppercase letter at least one number or symbol different from the old password If you change your password, make sure to create a new backup of your patient data immediately! Indeed, to restore a backup file, the password is required that was used upon creation of the backup file, so keep it synchronised with your new password to avoid any future confusion. FORGOTTEN PASSWORD
If you have forgotten your password:• make sure you are connected to the internet click the ‘Forgotten password?' button in the login screen fill in your login name (not case-sensitive) fill in your e-mail address (not case-sensitive); if you want to change the e-mail address linked to your login name, mail to [email protected] indicating your old and new e-mail address click the ‘Send' button to ask for a new password; a new password will be automatically sent to your e-mail address click the ‘Cancel' button to return to the login screen for login with your old password To log on for the first time after asking for a new password:• make sure you are connected to the internet to activate your new password if you are not connected to the internet, you will be prompted to log on with your old password When using your new password for the first time, we strongly advise you to change your new password to a personalised password, which will be easier to remember. Make sure to create a new backup of your patient data immediately afterwards! Indeed, to restore a backup file, the password is required that was used upon creation of the backup file, so keep it synchronised with your new password to avoid any future confusion. Start new patient file: enter baseline data of a new patientA new patient is a patient who has not previously been entered in the program. Baseline data must be completed before any visit data can be entered.
Existing patient file: a patient whose baseline data have previously been completed → enter data of a follow-up visit for an existing patient → review/modify baseline data of an existing patient → review/modify visit data of an existing patient → export UPDRS III data of an existing patient → change patient identification → delete patient data → view a list of the total patient population, displaying the baseline data and the data of the last visit for each → select a subpopulation of patients based on one or more criteria Export to Excel: export the data of the total patient population to ExcelFor each patient, only baseline data and the data of the last visit will be exported.
Backup & restore: → create a backup of all patient data → restore an existing backup file Main navigation : return to the home page without saving data get more information about the current page minimise the screen close the program Cancel: return to the home page without saving dataNext: continue to the next page Previous: return to the previous page Save: save data and return to the home page ENTER DATA
START NEW PATIENT FILE
Patient identification: Enter either a patient name (last name, first name) or a patient file number (maximum 30 characters). The program does not allow to enter a patient identification which is already in use. Baseline data must be completed before any visit data can be entered.
Start new patient file: enter baseline data of the new patient EXISTING PATIENT FILE
Patient identification: select an existing patient from the list An existing patient is a patient whose baseline data have previously been completed. Patient identifications are automatically sorted numerically and alphabetically. To search faster in a long list, click on the ‘Choose from list' bar and type the first letter/number of the patient identification. You will be redirected to all patient identifications starting with this letter/number. Start follow-up visit: enter data of a follow-up visit for the selected patient Review baseline data: review/modify baseline data of the selected patient Change patient identification: change name or file number of the selected patient Delete patient: delete all baseline and visit data of the selected patient from the database Previous visits: select the date of the visit you want to review/modify Review visit data: review/modify visit data of the selected patient for the selected visit Export UPDRS III data: export UPDRS III data of the selected patient for the selected visit to an external Excel file (.xls) Baseline data are data concerning demographics, diagnostic history, treatment history and progression history. These data are gathered retrospectively. It is mandatory to choose an option or to fill in a value for all baseline variables. Tick or choose the ‘Not known' option if you don't have any information about a certain variable. The baseline data only have to be entered once for each patient.
Demographics• Sex Options: male/female • Date of birth Options: day, month, year (DD/MM/YYYY): choose from calendar or fill in the input field (separate day, month and year by a slash)The date of birth is assumed to be a real date between 01/01/1900 and the current date.
Diagnostic history• Year of symptom onset Definition: year of symptom onset Options: year (YYYY)/not known It is assumed that the year of symptom onset cannot precede the year of birth.
• Year of diagnosis Definition: year of diagnosis of Parkinson's disease (PD) Options: year (YYYY)/not known It is assumed that diagnosis cannot be made before symptom onset. • Weight at diagnosis Definition: weight at PD diagnosis Options: weight (kg)/not known It is assumed that weight at diagnosis is between 20 and 200 kg.
• Motor symptom type Definition: predominant motor symptom type at diagnosis Options: tremor predominant/akinetic-rigid predominant/mixed/not known Definition: laterality of motor symptoms at initial diagnosis Options: predominant left/predominant right/no predominant side/not known Treatment history• Antiparkinsonian drugs Definition: Were antiparkinsonian drugs administered during a period long enough to be relevant and at a dose high enough to be potentially effective? Options: yes/no/not known • Year of treatment start Definition: year of first relevant antiparkinsonian treatment with potentially effective dose Options: year (YYYY)/not known It is assumed that treatment is not started before diagnosis is made.
• Drug category Definition: category of first drug(s) received after diagnosis of Parkinson's disease during a period long enough to be relevant and at a dose high enough to be potentially Options: dopamine agonist/levodopa/COMT inhibitor/MAO-B inhibitor/other (amantadine, anticholinergic, etc.)/not known Treatment categories can be combined, except for the ‘Not known' category. It is assumed that a COMT inhibitor is always given in combination with levodopa. Progression history• Motor fluctuations Definition: year of onset of first motor fluctuations Options: year of onset (YYYY)/not known/not present It is assumed that motor fluctuations cannot be present before symptom onset.
Definition: year of onset of first dyskinesias Options: year of onset (YYYY)/not known/not present It is assumed that dyskinesias cannot be present before symptom onset.
Visit data can be completed for each patient at each visit. Tick or choose the ‘Not known' option if you do not have any information about a certain variable. Date of visit Definition: date of current visit Options: day, month, year (DD/MM/YYYY): choose from calendar or fill in the input field (separate day, month and year by a slash); by default, the date of recording is indicated in the calendar; if visit data are entered retrospectively, a date earlier than the current date should be chosen The visit date is assumed to be a real date between the patient's date of birth and the current date.
Copy the data of the last known follow-up visit into the new follow-up visit; UPDRS III, UPDRS IVb, UPDRS IVa and GDS scores are not copied. Definition: weight at current visit Options: weight (kg)/not known It is assumed that the weight is between 20 and 200 kg.
Motor impairment• Hoehn & Yahr stage Definition: Hoehn & Yahr stage of motor impairment in off/untreated state Options: score from 1 to 5/evaluation impossible/not performed 1 = Unilateral disease 1.5 = Unilateral plus axial involvement 2 = Bilateral disease, without impairment of balance 2.5 = Mild bilateral disease, with recovery on pull test 3 = Mild to moderate bilateral disease; some postural instability; physically independent 4 = Severe disability; still able to walk or stand unassisted 5 = Wheelchair bound or bedridden unless aided The definition of each score can be consulted by clicking the sign next to the score list.
• Evaluation of motor symptoms Definition: total score of the Unified Parkinson's Disease Rating Scale (UPDRS) III motor examination at current visit, either in on/treated state or in off/untreated state Options: on/off; number between 0 and 108 Enter the UPDRS III score manually or click the UPDRS III calculator and fill the on-screen questionnaire to calculate the score. Filling in this field is optional.
• Evaluation of motor fluctuations Definition: presence of motor fluctuations at current visit Options: absent/present/not known It is optional to click the UPDRS IVb calculator and to fill the on-screen questionnaire.
• Evaluation of dyskinesias Definition: presence of dyskinesias at current visit Options: absent/present/not known It is optional to click the UPDRS IVa calculator and to fill the on-screen questionnaire.
Non-motor impairment • Cognitive decline Definition: presence of cognitive decline Options: absent/present/not known Definitions: score of the Mini-Mental State Examination at current visit Options: number between 0 and 30/not known Filling in this field is optional.
Definition: symptoms classified as depressive based on your clinical assessment, such as feelings of emptiness, hopelessness or inappropriate guilt, anhedonia, disturbed sleeping or eating habits, absence of positive thoughts or plans, etc.
Options: absent/present/not known Definition: total score of the 15-item short form of the Geriatric Depression Scale (GDS-15) at current visit Options: number between 0 and 15 Enter the GDS-15 score manually or click the GDS calculator and fill the on-screen questionnaire to calculate the score. Filling in this field is optional.
• Psychosis/hallucinations Definition: presence of psychosis or hallucinations Options: absent/present/not known • Sleep disorders Definition: sleep disturbances such as sleep fragmentation, rapid eye movement behaviour disorder, excessive daytime sleepiness, restless legs syndrome, altered sleep wake cycle, insomnia, etc.
Options: absent/present/not known • Symptoms suggestive of Definition: symptoms suggestive of orthostatic hypotension orthostatic hypotension Options: absent/present/not known • Professionally active Definition: Is the patient professionally active at the time of the current visit? Options: yes/no/not known Definition: patient ‘s residence at the current visit Options: living at home/institutionalised/not known Current treatment • Antiparkinsonian drugs Definition: Did the patient take antiparkinsonian drugs during the last weeks before the current visit? Options: yes/no/not known Definition: brand name of the antiparkinsonian drugs Options: Duodopa/Prolopa/Prolopa HBS/Sinemet/Stalevo/Mirapexin/ It is mandatory to choose an option from the list if you indicated that the patient was taking antiparkinsonian drugs during the last weeks before the current visit. If the patient was taking more than one type of antiparkinsonian medication, indicate each brand name in subsequent lists. Definition: total daily dose of the antiparkinsonian drug that the patient was taking during the last weeks before the current visit, expressed in mg active substance Options: number between 0 and 9999 (1 decimal possible for numbers less It is mandatory to fill in a value if you indicated that the patient was taking antiparkinsonian drugs during the last weeks before the current visit. If the patient was taking more than one type of antiparkinsonian medication, indicate the total daily dose of each drug in subsequent lists. • Daily intakes Definition: number of daily intakes of the antiparkinsonian drug that the patient was taking during the last weeks before the current visit Options: number between 1 to 10; if the drug is continuously administered (Duodopa), choose ‘1' for the number of daily intakes It is mandatory to fill in a value if you indicated that the patient was taking antiparkinsonian drugs during the last weeks before the current visit. If the patient was taking more than one type of antiparkinsonian medication, indicate the number of daily intakes of each drug in the subsequent lists. Definition: Did the patient take drugs other than antiparkinsonian drugs during the last weeks before the current visit? Options: yes/no/not known Other drug category Definition: category of drugs other than antiparkinsonian drugs that the patient was taking during the last weeks before the current visit Options: antidepressant/cholinesterase (ChE) inhibitor/antipsychotic drug/ antihypotensive drug/GI motility enhancing drug/sleep tablet/other/not known • Physiotherapy Definition: Did the patient get physiotherapy in the last weeks before the current visit? Options: yes/no/not known • Other intervention Definition: other treatments that the patient received in the weeks before the current visit e.g. surgery, non-pharmacological measures, etc.
Options: free text field UPDRS III total motor score
To calculate the patient's total score of the Unified Parkinson's Disease Rating Scale (UPDRS) III motor examination* at the current visit: indicate whether the patient is currently in the on/treated state or in off/untreated state indicate a score between 0 and 4 for each item (items 18 to 31) The definition of each score can be consulted by clicking the sign next to the score list Page 1/4Item 18 Facial expression Tremor at rest: head, upper and lower extremities Action or postural tremor of hands Page 2/4Item 22 Rigidity: judged on passive movement of major joints with patient relaxed in sitting position; cogwheeling to be ignored Page 3/4Item 23 Finger taps: patient taps thumb with index finger in rapid succession Hand movements: patient opens and closes hands in rapid succession Rapid alternating movements of hands: pronation-supination movements of hands, vertically and horizontally, with as large an amplitude as possible, both hands simultaneously Leg agility: patient taps heel on the ground in rapid succession picking up entire leg; amplitude should be Page 4/4Item 27 Arising from chair: patient attempts to rise from a straightbacked chair, with arms folded across chest Postural stability: response to sudden, strong posterior displacement produced by pull on shoulders while patient erect with eyes open and feet slightly apart; patient is prepared Body bradykinesia and hypokinesia: combining slowness, hesitancy, decreased armswing, small amplitude, and poverty of movement in general Save & Return: save the UPDRS III data and return to the visit data screen; the UPDRS III score and the patient's state during the examination will automatically be filled in on the visit data screen *Reproduced with permission from: Fahn S, Elton RL, Members of the UPDRS Development Committee. The Unified Parkinson's Disease Rating Scale. In Fahn S, Marsden CD, Calne DB, Goldstein M, eds: Recent Developments in Parkinson's Disease, Vol. 2. Florham Park, NJ: Macmillan Healthcare Information, 1987. pp. 153-163, 293-304.
UPDRS IVb score (motor fluctuations)
To evaluate motor fluctuations, indicate a score between 0 and 4 for each item (items 36 to 39) of the Unified Parkinson's Disease Rating Scale (UPDRS) IVb questionnaire*. The definition of each score can be consulted by clicking the sign next to the score list.
Save & Return: save the UPDRS IVb data and return to the visit data screen *Reproduced with permission from: Fahn S, Elton RL, Members of the UPDRS Development Committee. The Unified Parkinson's Disease Rating Scale. In Fahn S, Marsden CD, Calne DB, Goldstein M, eds: Recent Developments in Parkinson's Disease, Vol. 2. Florham Park, NJ: Macmillan Healthcare Information, 1987. pp. 153-163, 293-304.
UPDRS IVa score (dyskinesias)
To evaluate dyskinesias, indicate a score between 0 and 4 for each item (items 32 to 35) of the Unified Parkinson's Disease Rating Scale (UPDRS) IVa questionnaire*. The definition of each score can be consulted by clicking the sign next to the score list.
Save & Return: save the UPDRS IVa data and return to the visit data screen *Reproduced with permission from: Fahn S, Elton RL, Members of the UPDRS Development Committee. The Unified Parkinson's Disease Rating Scale. In Fahn S, Marsden CD, Calne DB, Goldstein M, eds: Recent Developments in Parkinson's Disease, Vol. 2. Florham Park, NJ: Macmillan Healthcare Information, 1987. pp. 153-163, 293-304.
GDS-15 score
To calculate the patient's total score of the 15-item short form of the Geriatric Depression Scale (GDS-15)* at the current visit, indicate ‘yes' or ‘no' for each question. Save & Return: save the GDS-15 data and return to the visit data screen; the total GDS-15 score will automatically be filled in on the visit data screen *Yesavage JA, et al. J Psychiatr Res 17: 37-49, 1983; Sheikh JI, et al. Int Psychogeriatr 3: 23-28, 1991; http://www.stanford.edu/ yesavage/GDS.
english.short.score.html ANALYSE DATA
Only patients with baseline and visit data are included in the analysis. PATIENT (SUB)POPULATION LIST

Default display: total patient population list containing:
•
baseline data for all patients for whom at least one follow-up visit has been saved data of the last visit for all patients for whom at least one follow-up visit has been saved count of number of patients in the (sub)population list To navigate in the list: click the ,, or  buttons or use the scroll bars To sort the values in a single column: • click the column heading to sort the column values alphabetically or numerically click again the column heading to invert the sorting order To limit the patient variables to be displayed in this view:• click the ‘Selected patient variables' button To filter the patient population based on one or more criteria:• click the ‘Filter criteria' button To export the current selection to Excel:• click the ‘Export to Excel' button select a location for storage of the Excel file, indicate a file name and click the ‘Save' button only the displayed selection will be exported to Excel; if values in a single column are sorted, the exported patient order will be sorted in the same way SELECT VARIABLES (COLUMNS) TO BE DISPLAYED
To select patient variables to be displayed in the patient (sub)population list (columns):• click the ‘Selected patient variables' button tick the patient variables to be displayed as columns of the patient (sub)population list tick ‘Select all' to select all patient variables for display tick ‘Select none' to deselect all patient variables for display click the ‘Confirm' button to confirm your selection and return to the patient (sub)population list; at least one variable must be selected To filter the patient population based on one or more criteria:• click the ‘Filter criteria' button click the ‘Add filter' button to add a new filter choose a patient variable from the left box; filtering is also possible for patient variables that are not selected for display in the patient (sub)population list choose a criterion which should apply to the selected subpopulation (filter group) from the right boxe.g. to view all patients with MMSE score below 24, choose ‘MMSE score' as patient variable; choose ‘less than' as operator from the middle box; then fill in ‘24' as value in the input field click the ‘Add filter' button to add an extra filter: → only the subpopulation of patients fulfilling all filtering criteria simultaneously will be selected → the number of filters that can be added is unlimited → to select multiple criteria for a given patient variable: add an extra filter, select the given patient variable, choose a different criterion (e.g. Other drug category: Antidepressant and Antipsychotic); if both criteria are mutually exclusive, no patients will be displayed in the patient subpopulation list (e.g. Sex: Male and Female) click the ‘X' button to remove a single filter click the ‘Clear' button to clear all filters click the ‘Apply' button to apply all filtering criteria to the patient population: the patient subpopulation fulfilling all selected criteria will be displayed in the patient subpopulation list Patient variables: Definition and filter groups
Baseline variables (variable name_b) Definition: gender Filter groups: male/female Definition: age, calculated from year of birth and current year (years) Filter groups: < 50/50-59/60-69/≥ 70/not known • Age at symptom onset Definition: age at symptom onset, calculated from year of birth and year of symptom onset (years) Filter groups: < 50/50-59/60-69/≥ 70/not known • Disease duration Definition: duration of Parkinson's disease (PD), calculated from current year and year of symptom onset (years) Filter groups: < 5/5-9/10-14/15-19/≥ 20/not known • Age at diagnosis Definition: age at PD diagnosis, calculated from year of birth and year of diagnosis (years) Filter groups: < 50/50-59/ 60-69/≥ 70/not known • Yrs since diagnosis Definition: time since PD diagnosis, calculated from current year and year of diagnosis (years) Filter groups: < 5/5-9/10-14/15-19/≥ 20/not known • Yrs [symptom onset-diagnosis] Definition: time between symptom onset and diagnosis, calculated from year of diagnosis and year of symptom onset (years) Filter groups: <2/2-5/6-10/> 10/not known • Motor symptom type Definition: predominant motor symptom type at diagnosis Filter groups: tremor predominant/akinetic-rigid predominant/mixed/not known Definition: laterality of motor symptoms at initial diagnosis Filter groups: predominant left/predominant right/no predominant side/not known • Antiparkinsonian drugs Definition: Were antiparkinsonian drugs administered during a period long enough to be relevant and at a dose high enough to be potentially effective? Filter groups: yes/no/not known • Age at treatment start Definition: age at first relevant antiparkinsonian treatment with potentially effective dose, calculated from year of birth and year of treatment start (years) Filter groups: < 50/50-59/60-69/≥ 70/not known • Treatment duration Definition: time since first relevant antiparkinsonian treatment with potentially effective dose, calculated from current year and year of treatment start (years) Filter groups: <2/2-5/6-10/> 10/not known • Yrs [symptom onset-treatment] Definition: time between symptom onset and first relevant antiparkinsonian treatment with potentially effective dose, calculated from year of symptom onset and the year of treatment start (years) Filter groups: <2/2-5/6-10/> 10/not known • Yrs [diagnosis-treatment] Definition: time between PD diagnosis and first relevant antiparkinsonian treatment with potentially effective dose, calculated from year of PD diagnosis and the year of treatment start (years) Filter groups: <2/2-5/6-10/> 10/not known • Drug category Definition: category of first antiparkinsonian treatment(s) received after diagnosis of PD during a period long enough to be relevant and at a dose high enough to be potentially effective - dopamine agonist- levodopa- MAO-B inhibitor combination therapy: - including dopamine agonist- including levodopa- including COMT inhibitor- including MAO-B inhibitor other treatmentnot known Visit variables (variable name_v) • Hoehn & Yahr stage Definition: Hoehn & Yahr stage of motor impairment in off/untreated state Unilateral disease 1.5 = Unilateral plus axial involvement2 = Bilateral disease, without impairment of balance 1.5= Mild bilateral disease, with recovery on pull test3 = Mild to moderate bilateral disease; some postural instability; physically independent Severe disability; still able to walk or stand unassisted Wheelchair bound or bedridden unless aided Evaluation impossibleNot performed • Motor fluctuations Definition: presence of motor fluctuations at last visit Filter groups: absent/present/not known Definition: presence of dyskinesias at last visit Filter groups: absent/present/not known • Cognitive decline Definition: presence of cognitive decline Filter groups: absent/present/not known Definition: Mini-Mental State Examination score at last visit Filter: equals/less than/greater than number between 0 and 30 Definition: symptoms classified as depressive based on your clinical assessment, such as feelings of emptiness, hopelessness or inappropriate guilt, anhedonia, disturbed sleeping or eating habits, absence of positive thoughts or plans, etc.
Filter groups: absent/present/not known • Psychosis/hallucinations Definition: presence of psychosis or hallucinations Filter groups: absent/present/not known • Sleep disorders Definition: sleep disturbances such as sleep fragmentation, rapid eye movement behaviour disorder, excessive daytime sleepiness, restless legs syndrome, altered sleep/wake cycle, insomnia, etc.
Filter groups: absent/present/not known • Orthostatic hypotension Definition: symptoms suggestive of orthostatic hypotension Filter groups: absent/present/not known • Professionally active Definition: Was the patient professionally active at the time of the last visit? Filter groups: yes/no/not known Definition: patient's residence at the last visit Filter groups: living at home/institutionalised/not known • Antiparkinsonian drugs Definition: Did the patient take antiparkinsonian drugs in the weeks before the Filter groups: yes/no/not known Definition: Did the patient take drugs other than antiparkinsonian drugs in the weeks before the last visit? Filter groups: yes/no/not known • Other drug category Definition: category of drugs other than antiparkinsonian drugs that the patient was taking in the weeks before the last visit Filter groups: antidepressant/cholinesterase (ChE) inhibitor/antipsychotic drug/ antihypotensive drug/GI motility enhancing drug/sleep tablet/other/not known • Physiotherapy Definition: Did the patient get physiotherapy in the weeks before the last visit? Options: yes/no/not known • Antiparkinsonian drug brand Definition: brand of antiparkinsonian drug(s) taken in the weeks before the last Filter groups: Duodopa/Prolopa/Prolopa HBS/Sinemet/Sinemet Control/ COPY DATA
EXPORT TO EXCEL
•
To export your total patient population to Excel: → click the ‘Export to Excel‘ button → click the next ‘Export to Excel‘ button → select the location for storage of the Excel file, indicate a file name and click the ‘Save‘ button This action will save the data of all patients in an external Excel file (.xls). Only baseline data and the data of the last visit are exported. BACKUP & RESTORE
Before creating a backup file, make sure that you are satisfied with your current password. If you change your password after creating a backup and you wish to restore this backup file afterwards, you may have to log on with the password used upon creation of the backup file! To create a backup file of all patient data:• click the ‘Browse' button to select a location for storage of the backup file; it is highly recommended to save the backup file on an external memory, e.g. a USB stick, a CD-ROM, a DVD, etc.
give the backup file a file name; by default, a file name containing the current date is suggested; the filename extension is free click the ‘Create backup' button; an encrypted backup file will be saved with the indicated name at the indicated location: → backup file cannot be used to analyse data in Excel or to consult data → decoding or restoring the backup file is only possible through the 4P Tool: your personal login name and password are required for this action Restore backupTo restore an existing backup file:• click the ‘Browse' button to locate the backup file click the ‘Restore backup' button to restore the backup file; after restoring the file, you are automatically redirected to the home page All changes to the patient data you made after creating your backup file will be lost when you restore this backup file. If you have changed your password after creating a backup and you wish to restore this backup file afterwards, you may have to log on with the password used upon creation of the backup file!

Source: http://www.4ptool.be/4PHelp.pdf