16. Wiener gesangswissenschaftliche Tagung – „Sprung in die Karriere 2" von Michael gerzaBek Am 16. April 2011, dem internationalen „Tag der Stimme", fand auf der Studiobühne des In- stituts für Gesang und Musiktheater der Universität für Musik und darstellenden Kunst Wien die 16. Wiener gesangswissenschaftliche Tagung statt. Die Fortsetzung des Themas „Sprung
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21st European Conference on Fracture, ECF21, 20-24 June 2016, Catania, Italy Fatigue microstructural evolution in pseudo elastic NiTi alloy Vittorio Di Coccoa*, Francesco Iacovielloa, Stefano Natalib aDICeM – University of Cassino and Southern Lazio, Cassino (FR) 03043, Italy bD.I.C.M.A - "La Sapienza" University, Rome 0018, Italy Abstract
NORDIC COCHRANE CENTRE PRESS RELEASE Brussels, 24 June 2014 EMA's new policy on access to clinical data: About to privatise pharmaceutical knowledge? The proof will be in the pudding The European Medicines Agency (EMA) has made known that its controversial policy on access to clinical data is to be adopted by mid-July 2014. In the aftermath of a public outcry that criticised the reversal of the draft policy proposal, the agency now claims that it will implement a more "user-friendly" system for researchers. Yet, serious concerns remain as other restrictive measures and legal loopholes are left unaddressed.
ABSTRACT BOOK The Third Annual UAE Epilepsy Congress and First Joint Emirati Saudi Meeting, April, 4th-5th, 2014, Grand Hyatt Hotel, Dubai, United Arab Emirates Guest Editor: Taoufik Alsadi1 1Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates Abstract of Presentations thereby permitting individually targeted preventive
16 COM2 (RS-485) Communication Start: D1214（K512） End: D1215（K895） 17 DC Power input 18 2 pin removable terminal (standard D0 D199 D200 D999 Factory setting is 19 Power input cable (standard Factory setting is latched. Some are latched and can't Non-latched (fixed) Start: D1216 (K200) Start: D1218 (K2,000) 20 Battery cover End: D1217 (K999) End: D1219 (K4,999)
Eurasian Harm rEduction nEtwork Hepatitis corrElation ProjEct drug use: harm reduction The Correlation project is co-funded by the European Commission under the Programme of Community Action in the field of Public Health 2008 – 2013. Neither the European Commission nor any person acting on its behalf is liable for any use of information contained in this publication.
BIOMEDICAL ENGINEERING & OMICS BACTERIAL DNA & LAB 1; LAB SAFETY & NOTEBOOKS Dawn M. Kilkenny, PhD January 9th, 2013 Institute of Biomaterials andBiomedical Engineering Bacteria as a Bioengineering Tool n Mammalian genes are routinely put into bacteria in order to synthesize products for medical treatment and commercial use (i.e., human insulin, human growth hormone, vaccines, etc.)
Inside this issue:Pg 1 Drought brokenPg 1 Dr Greg Tate retiredPg 2 Nitrogen EfficiencyPg 3 Green grass in a drought Pg 3 Hauraki Plains HempPg 3 The EF Maize BlockPg 4 Fluoridation Pg 5 Farming controversiesPg 5 Thoughts to ponderPg 6 Why foliar spray
EÖtupon Te˜uqoc No. 7 — >Oktwbrioc 2001 A tutorial on character code issues Jukka K. Korpella Päivänsäteenkuja 4 as. 1FIN-02210 EspooFinlandEmail : [email protected] In computers and in data transmission between them, i.e. in digital data processing and transfer, data is internally presented as octets, as a rule. Anoctet is a small unit of data with a numerical value between 0 and 255, in-clusively. The numerical values are presented in the normal (decimal) notationhere, but notice that other presentations are used too, especially octal (base
Generic Entry, Pay-for-Delay Settlements, and the Distribution of Surplus in the US Pharmaceutical Ruben Jacobo-Rubio∗ John L. Turner† Jonathan W. Williams‡ Using an event study approach, and unique data on Paragraph (iv) pharmaceuticalpatent litigation decisions, we estimate that brand firms value deterrence at $4.6 bil-lion on average while generic entrants value the right to enter, on average, at $236.8million. These estimates account for probabilistic district court decisions and an ap-pellate process. In 2002, the Schering-Plough vs. FTC decision led to a surge in"pay-for-delay" settlements. We estimate that surpluses at stake in decided cases are73% lower after this decision, reducing the direct (per-case) consumer surplus gainsanticipated by the 1984 Hatch-Waxman Act's procedures for early generic entry.
For Alumni potlight And Friends Of East High January 2009 East High Alumni Heritage Hall: Angels Making History Newly inducted "Angels" prepare to cut the ribbon on the Heritage Hall dis-play, left to right, Anthony Ortega, Barry Hirschfeld, Philip Bailey, Allegra The Alumni Heritage Hall display is on the third floor outside of the East library.
RICHARD G.M. MORRIS MA, D.Phil, FRSE, FMedSci, CBE, FRS Centre for Cognitive and Neural Systems, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, United Kingdom. Tel: +44(0) 131 650 3518; Fax: +44(0) 131 651 1835; Mobile: +44 (0) 773 647 7190 27 June 1948; Worthing, England.
CATHOLIC DISTRICT SCHOOL BOARD OF EASTERN ONTARIO Active Teachers Great-West Life is a leading Canadian life and health insurer. Great-West Life's financial security advisors work with our clients from coast to coast to help them secure their financial future. We provide a wide range of retirement savings and income plans; as well as life, disability and critical illness insurance for individuals and families. As a leading provider of employee benefits in Canada, we offer effective benefit solutions for large and small employee groups. Great-West Life Online Information and details on Great-West Life's corporate profile, our products and services, investor information, news releases and contact information can all be found at our website www.greatwestlife.com. Great-West Life's Toll-Free Number To contact a customer service representative at Great-West Life for assistance with your medical and dental coverage, please call 1-800-957-9777.
Material Safety Data Sheet Revision Number: 008.0 Issue date: 05/06/2014 1. PRODUCT AND COMPANY IDENTIFICATION Product name: LOCTITE® 271™ THREADLOCKER IDH number: HIGH STRENGTH PART NO. 27131 Product type: Anaerobic Sealant Item number:
Chapter 12 Closer to the Truth: A New Model Theoryfor HPSG Frank RichterEberhard Karls Universit¨at T ¨ubingenT ¨ubingen, [email protected] The paper proceeds in three steps. Section 12.3 reviews problems with models of typical grammars (irrespective HPSG is a model theoretic grammar framework in which
Roebuck Bay, EAAF SIS Information Sheet on Flyway Network Sites Available for download from http://www.eaaflyway.net/information-sites-maps.php Categories approved by Second Meeting of the Partners Partnership for the East Asian- Australasian Flyway Beijing, China 13-14 November 2007 Report (Minutes) Agenda Item 3.13 Notes for compilers:
Año 106 // 3ª etapa // 451 // Viernes 18 de marzo de 2016 El PeruDIAan NORMAS LEGALES. LINEAMIENTOS PARA LA HOY EN VARIEDADES. lde Mongrut. Pá TRANSFERENCIA DE GESTIÓN DE LAS ENTIDADES TATUAJES, INMORTALIDAD DEL GOBIERNO. RES. DIRECTORAL Nº 088-2016-CGONPE FUNDADO EL 22 DE OCTUBRE DE 1825 POR EL LIBERTADOR SIMÓN BOLÍVAR
instructieboek / Instruction leaflet / Bedienungsanleitung / livret d'instructions/ Manuale di istruzioni / folleto de instrucciones / Manual de instruções PAC 12&14 MOBILE Air conditioner/Dehumidifier MOBILE Klimaanlage/Luftentfeuchter Condizionatore/umidificatore MOBILE Aire acondicionado / deshumidificador PORTÁTIL
Human Reproduction, Vol.24, No.3 pp. 602 – 607, 2009 Advanced Access publication on December 17, 2008 ORIGINAL ARTICLE Gynaecology Preoperative work-up for patients withdeeply inﬁltrating endometriosis:transvaginal ultrasonography mustdeﬁnitely be the ﬁrst-line imagingexamination Mathilde Piketty1, Nicolas Chopin1, Bertrand Dousset2,Anne-Elodie Millischer-Bellaische3, Gilles Roseau1, Mahaut Leconte2,Bruno Borghese1,4,5, and Charles Chapron1,4,5,6
European Journal of Economic and Social Systems 14 N° 3 (2000) 229-270 Innovation networks and competitive coalitions in the pharmaceutical industry: The emergence and structures of a new industrial organization MARC-HUBERT DEPRET* AND ABDELILLAH HAMDOUCH** Abstract. – Today, the pharmaceutical industry is subjected to wide-scale
Case-Report Facialisparese Das Krankheitsbild: Periphere Fazialisparese Anatomie: Von seinem Kerngebiet im Hirnstamm zieht der Gesichtsnerv durch den inneren Gehörgang in Nach-barschaft zum VIII. Hirnnerven nach lateral und durchläuft in einem geschwungenen Weg, eingebet-tet in seinen knöchernen Kanal, das Felsenbein. Im Bereich des Mittelohrs verlassen ihn sekretorische (Tränen- und Speicheldrüsen), gustatorische (vordere zwei Drittel der Zunge) und motorische (Stapediusmuskel) Abgänge. Nach Austritt aus dem Foramen styloideum zieht er in die Parotis und teilt sich dort im Pes anserinus in die Äste zur mimi-schen Gesichtsmuskulatur auf. Eine grobe Einteilung unterscheidet die fünf Hauptäste: der Zervi-kalast zum Platysma, der Ramus marginalis mandibulae zum Mund, der Bukkalast, der Augen- und der Stirnast (18).
36V 14.5Ah eZee Flat BatteryCustomized for Grin Tech Specifications and User Guide 35 cm (13.75") Grin Technologies Ltd.20 E 4th AveVancouver, BC, CanadaV5T 1E8 Copyright © 2012 Congratulations on your purchase of this 36V 14.5Ah lithium manganese ebike battery pack. Our hope is that it provides you with a solid 2-3 years of trouble-free power for your vehicle project.
Evidence that cranberry juice may improve augmentationindex in overweight men Guillaume Ruel, Annie Lapointe, Sonia Pomerleau, Patrick Couture, Simone Lemieux,Benoît Lamarche, Charles Couillard Institute of Nutraceuticals and Functional Foods, Université Laval, Québec (Canada), G1V 0A6 The stiffening of arteries is a key step in atherogenesis leading to cardiovascular disease. It
Contraceptive Use and Discontinuation Patterns in Nepal: Norplant, IUCD, Pill, and Injectables ©2003 EngenderHealth I. Introduction The main aims of Nepal's family planning program are to assist individuals and couples to space their children, prevent unintended pregnancies, and improve their overall reproductive health.
Eur J Ophthalmol 2014; 00 (00): 000-000 DOI: 10.5301/ejo.5000463 ORIGINAL ARTICLE Safety and efficacy of combined immunosuppression and orbital radiotherapy in thyroid-related restrictive myopathy: two-center experience Nikolaos T. Chalvatzis1,2, Argyrios K. Tzamalis1, Georgios K. Kalantzis2,3, Nabil El-Hindy3, Stavros A. Dimitrakos1, Michael J. Potts2
American Journal of Transplantation 2006; 6: 1639–1645 2006 The Authors Journal compilation C 2006 The American Society of Transplantation and the American Society of Transplant Surgeons Urine NGAL and IL-18 are Predictive Biomarkers forDelayed Graft Function Following KidneyTransplantation C. R. Parikha, A. Janib, J. Mishrac, Q. Mac,
Acupuncture and Schizophrenia – Effect and Acceptability:Preliminary results of the first UK studyPatricia Ronan, Dominic Harbinson, Douglas MacInnes, Wendy Lewis, After several years of planning, we have just completed the intervention phase of a small, pre-clinical pilot study to explore the acceptability and effects of
1500 Sunset Blvd. Houston, Texas 77005 An adventure of the spirit March 8, 2016 / Adar I 28, 5776 Volume 70 Number 12 From Rabbi Hayon Spring Series of Welcome Events for Rabbi Hayon Announced I have just returned from spending a week with at the annual convention of the Central Conference of By the time this Temple Bulletin hits your email in-
epidemiology Biostatistics and public Health - 2013, volume 10, number 2 SyStematic reviewS and meta- and pooled analySeS A systematic review of the cost-effectiveness of lifestyle modification as primary prevention intervention for diabetes mellitus type 2 Katrin I. Radl(1), Carolina Ianuale(2), Stefania Boccia(2) Background: diabetes is one of the leading causes of death, and has a huge economic impact on the burden of society. Lifestyle interventions such as diet, physical activity and weight reducing are proven to be effective in the prevention of diabetes. To encourage policy actions, data on the cost-effectiveness of such strategies of prevention programmes are needed. MeThods: a systematic review of the literature on the cost-effectiveness of prevention strategies focusing on lifestyle interventions for diabetes type 2 patients. a weighted version of drummond checklist was used to further assess the quality of the included studies. resuLTs: six studies met the inclusion criteria and were therefore considered in this paper. Intensive lifestyle intervention to prevent diabetes type 2 is cost-effective in comparison to other interventions. all studies were judged of medium-to-high quality.concLusIons: policy makers should consider the adoption of a prevention strategy focusing on intensive lifestyle changes because they are proven to be either cost-saving or cost-effective.
Endometriosis and Infertility Epidemiology and Evidence-based Treatments EBIHA OZKAN,a WILLIAM MURK,b AND AYDIN ARICI aDepartment of Obstetrics and Gynecology, Kocaeli University School of Medicine, bDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University
INTRODUCTIONA full third of the population needs glasses and contact lenses in order to see things in focus. This is caused by common conditions called myopia, hyperopia and astigmatism. The 20th century was the century of many inventions in medicine – this includes the invention of laser refractive surgery, which allowed millions of individuals to get rid of visual aids or at least decrease their use greatly.
LAND DER PALMEN UND BLUMEN Blumenriviera – Côte d'Azur Die Côte d'Azur – wie die französische Riviera genannt wird – ist wohl das schönste Stück Erde in Europa. Das azurblaue Meer, die roten und gelben Felsen, die sich im klaren Wasser spiegeln, die subtropischen Pflanzen wie Palmen, Zitronen- und Orangenbäume, das pulsierende Leben in den
Our Vision Corporate responsibility drives our core values here at Jasper & Jasper. The J&J range has been designed solely to provide cigarette users with an innovative, enjoyable and authentic alternative to conventional cigarettes. By eliminating harmful smoke pollution and litter associated with conventional cigarettes, we're working towards a cleaner environment
Hydroxyurea Treatment for Sickle Cell Disease Before hydroxyurea After hydroxyurea Hydroxyurea Treatment for Sickle Cell Disease This document is not intended to take the place of the care and attention of your personal physician. Our aim is to promote active participation in your care and treatment by providing information and education. Questions about individual health concerns or specifi c treatment options should be discussed with your physician. For more general information on sickle cell disease, please visit our Web site at www.stjude.org/sicklecell.
Application of Basic Science to Clinical Problems: Traditional vs. Hybrid Problem- Based LearningAmber N. Callis, D.D.S., M.S.; Ann L. McCann, R.D.H., Ph.D.; Emet D. Schneiderman, Ph.D.; William J. Babler, Ph.D.; Ernestine S. Lacy, D.D.S.; David Sidney Hale, D.D.S., M.S.D.Abstract: It is widely acknowledged that clinical problem-solving is a key skill for dental practitioners. The aim of this study was to determine if students in a hybrid problem-based learning curriculum (h-PBL) were better at integrating basic science knowl-edge with clinical cases than students in a traditional, lecture-based curriculum (TC). The performance of TC students (n=40) was compared to that of h-PBL students (n=31). Participants read two clinical scenarios and answered a series of questions regarding each. To control for differences in ability, Dental Admission Test (DAT) Academic Average scores and predental grade point aver-ages (GPAs) were compared, and an ANCOVA was used to adjust for the significant differences in DAT (t-test, p=0.002). Results showed that h-PBL students were better at applying basic science knowledge to a clinical case (ANCOVA, p=0.022) based on overall scores on one case. TC students' overall scores were better than h-PBL students on a separate case; however, it was not statistically significant (p=0.107). The h-PBL students also demonstrated greater skills in the areas of hypothesis generation (Mann-Whitney U, p=0.016) and communication (p=0.006). Basic science comprehension (p=0.01) and neurology (p<0.001) were two areas in which the TC students did score significantly higher than h-PBL students.
Comparison of Approaches toward Formalising Context: Implementation Characteristics and Capacities William Loyola Escuela de Postgrado en Administración de Empresas, Escuela Superior Politécnica del Litoral, Guayaquil, Ecuador [email protected] Abstract: Existing relevant literature regarding approaches to context formalisation is analysed in search of a characterisation that explains the links - suggested by knowledge theory of the firm - between knowledge integration capability and common knowledge types. The ontological and the syntactic-semantic-pragmatic continuum approaches reveal an extensive description of context, which contributes to the understanding of the knowledge integration process, and to an eventual operationalisation of common knowledge types. This theoretical development opens possibilities for the elaboration of prescriptive models that support the integration of knowledge during routine operations of the organisation. Keywords: knowledge integration, common knowledge, context formalisation 1. Common knowledge in
Body site distribution of skin cancer, pre-malignant and common benign pigmented lesions excised in general practice
Body site distribution of skin cancer, pre-malignant and common benign pigmented lesions excised in general practicePhilippa H. YoulUniversity of Queensland Monika JandaQueensland University of Technology Joanne F. AitkenUniversity of Queensland Chris B. Del MarBond University, [email protected] David C. WhitemanQueensland Institute of Medical Research
from World on the Edge: How to Prevent Environmentaland Economic Collapse, by Lester R. Brown© 2011 Earth Policy Institute We need an economy for the twenty-first century, onethat is in sync with the earth and its natural support sys-tems, not one that is destroying them. The fossil fuel-based, automobile-centered, throwaway economy thatevolved in western industrial societies is no longer aviable model—not for the countries that shaped it or forthose that are emulating them. In short, we need to builda new economy, one powered with carbon-free sources ofenergy—wind, solar, and geothermal—one that has adiversified transport system and that reuses and recycleseverything.
The Right to Parenthood An Argument for a Narrow Interpretation1 ABSTRACTThe paper argues for two kinds of limitations on the right to parenthood. First, it claims that the right to parenthooddoes not entail a right to have as many children as one desires. This conclusion follows from the standard justificationsfor the right to parenthood, none of which establishes the need to grant special protection to having as many childrenas one desires. Second, with respect to the right to receive assistance from the state in IVF, it is suggested that the stateshould also be allowed to take non-medical considerations into account in determining whether or not an applicant isentitled to this service, particularly in cases where the applicant seems to lack mothering ability.
Biochemical Systematics and Ecology 30 (2002) 837–854 Phytochemical variation within populations of Echinacea angustifolia (Asteraceae) Shannon E. Binns a, John T. Arnason a,∗, Bernard R. Baum b a Biology Department, University of Ottawa, 30 Marie Curie St., Ottawa, ON K1N 6N5, Canada b Eastern Cereal and Oilseed Research Centre, Agriculture and AgriFood Canada,
Drug Testing in Oral FluidOlaf H Drummer Victorian Institute of Forensic Medicine and Department of Forensic Medicine, Monash University, 57-83 Kavanagh St, Southbank, Vic. 3006, Australia For correspondence: Prof Olaf Drummer e-mail: [email protected] Over the last decade there have been considerable developments in the use of oral ﬂ uid (saliva) for drug testing. Oral ﬂ uid can
Occupational Safety and Health Information Series A GUIDE TO THE This booklet was written by Dr Chris Walls with assistance from theOSH Departmental Medical Practitioners and Dr Julian Crane(Physician, Wellington), Dr Margaret Wilsher (Physician, Auckland)and Dr Colin Wong (Physician, Dunedin), members of the NODSAsthma Panel. Dr John Allen (Pukekohe), Dr Charles Skinner (Auckland) and DrRob Stewart (Auckland) provided a critique from a general practiceview point and their assistance is greatly appreciated.
LA FALTA DE RECURSOS FISCALES FRENA EL DESARROLLO REGIONAL EN MÉXICO. Dr. Eudoxio Morales Flores1 LA FALTA DE MÁS RECURSOS FISCALES, FRENAN EL DESARROLLO REGIONAL EN MEXICO En América Latina y de manera particular en México, la falta de recursos fiscales, así como la transparencia y el manejo poco ético de los mismos por una parte, y por otra la falta de
Fitness of Transgenic Mosquito Aedes aegypti MalesCarrying a Dominant Lethal Genetic System Blandine Massonnet-Bruneel1*, Nicole Corre-Catelin1, Renaud Lacroix1,2, Rosemary S. Lees3¤, Kim Phuc Hoang3, Derric Nimmo2, Luke Alphey2,3, Paul Reiter1* 1 Unite´ Insectes et Maladies Infectieuses, Institut Pasteur, Paris, France, 2 Oxitec Ltd, Oxford, United Kingdom, 3 Department of Zoology, University of Oxford, Oxford,
for Successful Produced by Sponsored by 834 Tips for Successful Online Instruction 2 Table of Contents A. Prepare thoroughly for facilitating synchronous events . . . . . . . . . . . . . 5 A. Selecting online instructors for success . . . . . . . . . . . . . . . . . . . . 47 1. Choose instructors based on competencies . . . . . . . . . . . . . . . . .472. Choose instructors with the right attitudes . . . . . . . . . . . . . . . . 473. Choose instructors with the right knowledge and skills . . . . . . . . . . .524. Take into account other considerations when choosing instructors . . . . . 52
Received 11.18.05 Revisions Received 1.26.06 Accepted 2.2.06 Validating New Reagents: Roadmaps Through the WildernessRoberta A. Martindale, BSc (MLS), MT(ASCP),1 George S. Cembrowski MD, PhD,1,2 Lucille J. Journault,1,2 Jennifer L. Crawford,BSc (MLS),1,2 Chi Tran,1,2 Tammy L. Hofer, BSc (MLS), MBA,1,2 Bev J. Rintoul, BSc (MLS)1,2 Jean S. Der,1,2 Cathy W. Revers, BSc (MLS),1,2 Cheryl A. Vesso,1,2 Carol E. Shalapay,1,2 Connie I. Prosser, PhD, FCACB,1,2 Donald F. LeGatt, PhD, FCACB1,2( 1Department of Laboratory Medicine and Pathology, University of Alberta Hospitals, 2Capital Health Authority, Edmonton, Canada)
Cross-national synthesis on education quality report no. 2: professional development and teachers' conceptions of education quality
American Institutes for Research Academy for Educational Development Aga Khan Foundation Two Case Studies in Public-Private Partnerships in Education in Rajasthan, India Discovery Channel Global Education Fund Education Development Center International Reading Association The Joseph P. K ennedy, Jr. Foundation
Nationale Konferenz Häusliche Gewalt als Thema der öffentlichen Gesundheit 20. November 2014 / Bern Opfer häuslicher Gewalt in der Gynäkologie und Geburtshilfe Sibil Tschudin Frauenklinik USB Häusliche Gewalt in Gynäkologie und Geburtshilfe Häusliche Gewalt im Zusammenhang mit Schwangerschaft und Geburt
Schizophrenia Research 63 (2003) 63 – 71 Source distribution of neuromagnetic slow-wave activity in schizophrenic patients—effects of activation Thorsten Fehr, Johanna Kissler, Christian Wienbruch, Stephan Moratti, Thomas Elbert, Hans Watzl, Brigitte Rockstroh * Department of Psychology, University of Konstanz, P.O. Box D23, D-78457 Konstanz, Germany Center for Psychiatry Reichenau, D-78467 Reichenau, Germany
Reprinted from FDA's website by Guidance for Industry Irritable Bowel Syndrome — Clinical Evaluation of Drugs for Treatment U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Clinical/Medical
Ethanol-Based Hand Sanitizing Gel Vapor Causes Positive Alcohol Marker, Ethylglucuronide, and Positive Breathalyzer Gregory E. Skipper, MD, Frieder Wurst, MD, Wolfgang Weinmann, MD, and Michael Liepman, MD Context: Ethylglucuronide (EtG), a minor metabolite of alcohol, is an Ethylglucuronide (EtG) is a nonoxidative metabolite of ethyl alcohol that has recently gained widespread use in monitor-
ACEMBL Expression System User Manual Vers. 09.11 Yan Nie, Christoph Bieniossek, Imre Berger ACEMBL was developed at the European Molecular Biology Laboratory EMBL Grenoble Outstation 38042 Grenoble CEDEX 9, France Grenoble, August 21, 2009 ACEMBL System User Manual EMBL Grenoble, 2009 Table of Contents
ANTIOXIDANTS & REDOX SIGNALINGVolume 15, Number 7, 2011 FORUM REVIEW ARTICLE ª Mary Ann Liebert, Inc.DOI: 10.1089/ars.2010.3739 Oxidative Stress as Pathogenesis of Cardiovascular Risk Associated with Metabolic Syndrome Metabolic syndrome (MetS) is characterized by accumulation of visceral fat associated with the clustering ofmetabolic and pathophysiological cardiovascular risk factors: impaired glucose tolerance, dyslipidemia, andhypertension. Although the definition of MetS is different among countries, visceral obesity is an indispensablecomponent of MetS. A growing body of evidence suggests that increased oxidative stress to adipocytes is centralto the pathogenesis of cardiovascular disease in MetS. Increased oxidative stress to adipocytes causes dysre-gulated expression of inflammation-related adipocytokines in MetS, which contributes to obesity-associatedvasculopathy and cardiovascular risk primarily through endothelial dysfunction. The purpose of present reviewis to unravel the mechanistic link between oxidative stress and cardiovascular risk in MetS, focusing on insulinresistance, hypertension, and atherosclerosis. Then, therapeutic opportunities translated from the bench tobedside will be provided to develop novel strategies to cardiovascular risk factors in MetS. Antioxid. RedoxSignal. 15, 1911–1926.