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REVIEW ARTICLE Current topical and systemic approaches to treatment of rosacea HC Korting,* C Schöllmann Department of Dermatology and Allergology, Ludwig-Maximilians-Universität, Munich, Germany *Correspondence: HC Korting. E-mail: h.c.korting@lrz.uni-muenchen.de Abstract Rosacea is a common, often overlooked, chronic facial dermatosis characterized by intermittent periods of exacerbation and remission. Clinical subtypes and grading of the disease have been defined in the literature. On the basis of a genetic predisposition, there are several intrinsic and extrinsic factors possibly correlating with the phenotypic expression of the disease. Although rosacea cannot be cured, there are several recommended treatment strategies appropriate to control the corresponding symptoms/signs. In addition to adequate skin care, these include topical and systemic medications particularly suitable for the papulopustular subtype of rosacea with moderate to severe intensity. The most commonly used and most established therapeutic regimens are topical metronidazole and topical azelaic acid as well as oral doxycycline. Conventionally, 100–200 mg per day have been used. Today also a controlled release formulation is available, delivering 40 mg per day using non-antibiotic, anti-inflammatory activities of the drug. Anti-inflammatory dose doxycycline in particular allows for a safe and effective short- and long-term therapy of rosacea. Topical metronidazole and topical azelaic acid also appear to be safe and effective for short-term use. There are indications that a combined therapy of anti-inflammatory dose doxycycline and topical metronidazole could possibly have synergy effects. Further interesting therapy options for the short- and long-term therapy of rosacea could be low-dose minocycline and isotretinoin; however, too little data are available with regard to the effectiveness, safety, optimal dosage and appropriate length of treatment for these medications to draw final conclusions. Received: 21 December 2007; Accepted 9 December 2008

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An interactive system for finding complementary literatures: a stimulus to scientific discovery Don R. Swanson* & Neil R. Smalheiser† *Division of the Humanities, The University of Chicago 1010 E. 59th St., Chicago, IL 60637 †Department of Pediatrics, MC 5058, The University of Chicago 5841 S. Maryland Ave., Chicago, IL 60637 An unintended consequence of specialization in science is poor communication across

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SATISFACCION Y PERDIDAS INTERMENSTRUALES CON EL USO CONSECUTIVO DE DISPOSITIVOS INTRAUTERINOS LIBERADORES DE LEVONORGESTREL Helsinki, Finlandia El uso consecutivo de dispositivos intrauterinos liberadores de levonorgestrel se asocia con una reducción de los días de sangrado y pérdidas intermenstruales, y con altos niveles de satisfacción respecto del tratamiento. Human Reproduction 25(6):1423-1427 Jun, 2010 Autores: Heikinheimo O, Inki P, Kunz M, Gemzell-Danielsson G Institución/es participante/s en la investigación: Helsinki University Central Hospital Título original: Predictors of Bleeding and User Satisfaction During Consecutive Use of the Levonorgestrel-Releasing Intrauterine System Título en castellano: Predictores de Hemorragia y Satisfacción de las Usuarias Durante el Uso Consecutivo de Dispositivos Intrauterinos Liberadores de Levonorgestrel Extensión del Resumen-SIIC en castellano: 2.64 páginas impresas en papel A4 Introducción El dispositivo intrauterino (DIU) liberador de levonorgestrel (LNG-DIU) se emplea en Finlandia desde 1990, actualmente se comercializa en más de 120 países y es uno de los dispositivos más usados, junto con el DIU con cobre, entre las mujeres europeas. La duración aprobada de uso es de 5 años. Entre aquellas mujeres que usan LNG-DIU, aproximadamente el 25% se encuentra utilizando su segundo dispositivo consecutivo. El uso del LNG-DIU se asocia con una alta tasa de amenorrea, que alcanza el 60%; en un ensayo clínico, este dispositivo mostró una alta tasa de continuidad, y reducción del sangrado o mantenimiento de la amenorrea durante el primer año de uso del dispositivo por segunda vez consecutiva. El uso de LNG-DIU se caracteriza por un patrón de sangrado irregular y pérdidas intermenstruales durante los primeros meses, que posteriormente disminuyen, a la vez que aumenta la tasa de amenorrea. Sin embargo, no se conocen con certeza los factores predictivos de este tipo de patrón de sangrado asociado al LNG-DIU; en un estudio, se determinó que existía una relación entre la presencia de oligomenorrea al cabo de un año de uso de LNG-DIU y factores tales como la duración basal de la menstruación inferior a los cinco días, el uso del dispositivo como método anticonceptivo y no como tratamiento de la menorragia, y la ausencia de menorragia previa. Sin embargo, no se han estudiado los factores que influyen en el patrón de sangrado durante el uso consecutivo de LNG-DIU. Este estudio tuvo por objetivo analizar los factores predictivos del patrón de sangrado durante el primer año de uso de un segundo LNG-DIU, en mujeres que habían empleado el primer LNG-DIU como anticonceptivo o como tratamiento de la menorragia.

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Society for Menstrual Cycle Research, 2011 Embodied Consciousness, Informed Choices: Critical Perspectives On the Menstrual Cycle June 2-4, 2011 Chatham University, Pittsburgh, PA Thank you to the following organizations for supporting this conference: Chatham University UPMC – Magee Women's Hospital of UPMC

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Signal Transduction Minocycline Targets the NF-kB Nexus through Suppressionof TGF-b1-TAK1-IkB Signaling in Ovarian Cancer Parvin Ataie-Kachoie1, Samina Badar1,2, David L. Morris1,2, and Mohammad H. Pourgholami2 Substantial evidence supports the critical role of NF-kB in ovarian cancer. Minocycline, a tetracycline, has been shown to exhibit beneficial effects in this malignancy through regulation of a cohort of genes thatoverlap significantly with the NF-kB transcriptome. Here, it was examined whether or not the molecularmechanism could be attributed to modulation of NF-kB signaling using a combination of in vitro and in vivomodels. Minocycline suppressed constitutive NF-kB activation in OVCAR-3 and SKOV-3 ovarian carci-noma cells and was correlated with attenuation of IkBa kinase (IKK) activation, IkBa phosphorylation anddegradation, and p65 phosphorylation and nuclear translocation. The inhibition of IKK was found to beassociated with suppression of TGF-b-activated-kinase-1 (TAK1) activation and its dissociation from TAK1-binding-protein-1 (TAB1), an indispensable functional mediator between TGF-b and TAK1. Further studiesdemonstrated that minocycline downregulated TGF-b1 expression. Enforced TGF-b1 expression inducedNF-kB activity, and minocycline rescued this effect. Consistent with this finding, TGF-b1 knockdownsuppressed NF-kB activation and abrogated the inhibitory effect of minocycline on this transcription factor.These results suggest that the minocycline-induced suppression of NF-kB activity is mediated, in part,through inhibition of TGF-b1. Furthermore, the influence of minocycline on NF-kB pathway activation wasexamined in female nude mice harboring intraperitoneal OVCAR-3 tumors. Both acute and chronicadministration of minocycline led to suppression of p65 phosphorylation and nuclear translocationaccompanied by downregulation of NF-kB activity and endogenous protein levels of its target gene products.These data reveal the therapeutic potential of minocycline as an agent targeting the pro-oncogenic TGF-b–NF-kB axis in ovarian cancer.

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The Open Clinical Chemistry Journal, 2009, 2, 7-11 7 Open Access Improvement of Phencyclidine-Induced Cognitive Deficits in Mice by Subsequent Subchronic Administration of Fluvoxamine, but not Sertraline Tamaki Ishima1, Yuko Fujita1, Mami Kohno1, Shinsui Kunitachi1, Mao Horio1, Yuto Takatsu1, Takahiko Minase1, Yuko Tanibuchi1,2, Hiroko Hagiwara1,2, Masaomi Iyo2 and Kenji Hashimoto1,*

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Organic Anion Transporter 3 Contributes to theRegulation of Blood Pressure Volker Vallon,*†‡ Satish A. Eraly,* William R. Wikoff,§ Timo Rieg,*‡ Gregory Kaler,*David M. Truong,* Sun-Young Ahn,* Nitish R. Mahapatra,* Sushil K. Mahata,*‡Jon A. Gangoiti,储 Wei Wu,* Bruce A. Barshop,储 Gary Siuzdak,§ and Sanjay K. Nigam*储¶ Departments of *Medicine, †Pharmacology, 储Pediatrics, and ¶Cellular and Molecular Medicine, University ofCalifornia, San Diego, ‡Department of Medicine, San Diego VA Healthcare System, and §Department of MolecularBiology and the Center for Mass Spectrometry, Scripps Research Institute, La Jolla, California

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PREVENCION E INTERVENCION CONTRA EL ACOSO ESCOLAR Capacitación del Empleado de la Corporación Escolar sobre la PrevenciónFuente: Departamento de Educación de Indiana Según la Asociación Nacional de Psicólogos Escolares, 160,000 estudiantes por día faltan a la escuela cada día a causa del acoso escolar (bullying) (Fried & Fried, 2003).

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Cervical insulin-like growth factor binding protein-1(IGFBP-1) to predict spontaneous onset of labor andinduction to delivery interval in post-term pregnancy OGL1,2, EIRIK SKOGVOLL3,4 & RUNA HEIMSTAD2,5 1Department of Gynecology and Obstetrics, Levanger Hospital, Health Trust Nord-Trøndelag, 2Department of Obstetrics,3Anaesthesiology and Emergency Medicine, St. Olav University Hospital Trondheim, 4Institute of Cancer research andMolecular Medicine, Faculty of Medicine, and 5Institute of Laboratory Medicine, Children's and Women's Health, NorwegianUniversity of Science and Technology (NTNU), Trondheim, Norway

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Current Treatment Options for Community-AcquiredMethicillin-Resistant Staphylococcus aureus Infection Robert C. Moellering, Jr. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts During the past decade, there has been a marked increase in the prevalence of community-acquired methicillin-resistant Staphylococcus aureus infection in the United States and elsewhere. The most common such infectionsare those involving the skin and skin structures. Although a number of these lesions (including small furunclesand abscesses) respond well to surgical incision and drainage, oral antimicrobial agents are commonly usedto treat these infections in outpatients. Unfortunately, with the exception of linezolid, none of the agentspresently being used in this fashion has been subjected to rigorous clinical trial. Thus, current therapy isbased largely on anecdotal evidence. For more-serious infections requiring hospitalization, parenteral anti-microbials such as vancomycin, teicoplanin, daptomycin, linezolid, and tigecycline are presently available andhave demonstrated effectiveness in randomized, prospective, double-blind trials.

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THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 53, Issue of December 31, pp. 55833–55839, 2004 © 2004 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. Hyperphosphorylation and Aggregation of Tau in ExperimentalAutoimmune Encephalomyelitis* Received for publication, August 30, 2004, and in revised form, October 6, 2004

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MIND: Modality Independent Neighbourhood Descriptor for Multi-Modal Deformable Mattias P. Heinricha,b,∗, Mark Jenkinsonb, Manav Bhushana,b, Tahreema Matind, Fergus V. Gleesond, Sir Michael Bradyc, Julia A. Schnabela aInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, UK bOxford University Centre for Functional MRI of the Brain, UK

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Medical Technology SA Volume 25 No. 1 June 2011 Peer reviewed rEviEW PATHOGENESIS AND FUTURE TREATMENTS OF SYSTEMIC LUPUS ERYTHEMATOSUS: THE ROLE OF CYTOKINES AND ANTI-CYTOKINES?W. J. MauleUniversity of Johannesburg, Department of Biomedical Technology, Faculty of Health Sciences, South Africa.email: warrenm@uj.ac.za tel: +27 (0)11 559 6265 fax: +27 (0)11 559 6558

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Academic Licensing Agreements Using Academic License Agreements To Promote Global Social Responsibility By Ashley J. Stevens D.Phil (Oxon) and April E. Effort I. Abstract Anderson, Anderson and Company; Alan Bennett, he impetus to use academic innovations to University of California Davis; Ian Bell and Angus Liv- enhance peoples' lives in the developing

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