Proceedings of the ASME 2010 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference August 15-18, 2010, Montreal, Quebec, Canada SYMBOLIC MATH-BASED BATTERY MODELING FOR ELECTRIC VEHICLE SIMULATION Aden N. Seaman John McPhee Department of Systems Design Engineering
Dslaboratories.ruREVITA HIGH PERFORMANCE HAIR GROWTH STIMULATING SHAMPOO PRODUCT INFORMATION BOOKLET Revita®, the most efficient hair-growth stimulating shampoo on the market, results from DS Laboratories' commitment to cutting-edge research.
Revita packs a powerful combination of active ingredients, free of sodium lauryl sulfate and sodium laureth sulfate (SLS/SLES). Revita is designed specifically to maintain scalp vitality and act against follicle dysfunction to achieve best results in a short time, whereas SLS/SLES are low- cost detergents used in mass-market shampoos and cleansers, often linked to skin drying, scalp irritation, and hair loss. Revita remains free of SLS/SLES, providing a high-quality scalp-safe shampoo product.
Revita was developed with cost as no object. Its compounds have been chosen exclusively for their hair-growth properties, quality, and efficacy, as opposed to brands designed mainly to be produced cheaply. The result is a high-quality shampoo with no real competitor, as Revita combines costly first-line compounds at high concentrations — 4% caffeine, 1% Pyrus malus (apple) seed extract, and 1% spin traps — to make Revita unique in its category.
CHEMICAL-FREE EXTRACTION To improve efficacy of this synergic combination, DS Laboratories developed a unique chemical-free extraction process that preserves the
clinical properties and efficacy of components. Through gentle mechanical compression, compounds are obtained as pure active molecules. Revita starts acting on your scalp, reviving hair follicles, from the first day of use. The time required to witness first results depends on severity
and duration of hair loss. No matter how extensive the loss, using Revita daily will improve the vitality of your scalp, maintaining the quality of your hair, and stimulating new hair growth.
Through the synergy of highly effective compounds, Revita maintains scalp vitality and acts against hair loss. By combining antioxidant and anti-androgen properties, plus powerful hydrating molecules, hair-growth stimulants, and amino acids, Revita delivers the most effective hair-growth shampoo available. Apple polyphenol (procyanidin B-2 and C-1). This phytochemical concentrate, found in the skin of unripe apples, acts as a potent
MECHANISM OF ACTION antioxidant. It protects cells against free radicals, the reactive atoms that contribute to tissue damage. These apple polyphenols are studied intensively in laboratories around the world for their health effects on various conditions, including hair loss. Studies show that after sequential use, an increase of almost 80 percent in hair diameter, plus an increase in total number of hairs, is achieved without side effects. In 2000, Japanese researchers presented their findings on the hair-growth effects of apple polyphenols, specifically procyanidin B-2. They identified two successful compounds, one from chardonnay grapes and one from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," wrote the research team, "shows the highest activity, of more than 300 percent relative to controls." MECHANISM OF ACTION The same year, in a double-blind placebo-controlled trial, 19 men with male pattern baldness applied a daily topical solution of 1% procyanidin B-2, extracted from apples. Ten other balding men served as controls. After six months, the study concluded: • The increase in terminal hairs and total number of hairs in the procyanidin B-2 group was significantly greater than in the controls. • Nearly 79 percent of subjects showed an increase in hair diameters.
• Procyanidin B-2 therapy showed great promise as a cure for male pattern baldness.
Following the discoveries, attempts were made to understand the mechanism by which the remarkable hair growth occurred. The headline from the prestigious British Journal of Dermatology proclaimed "Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study," [Br J Dermatol. 2002 Jan; 146(1): 41-51]. In this study, researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in hair growth. Procyanidin B-2 seems to promote growth by down regulating PKC in both the anagen (active) and telogen (resting) phases of the hair follicle. When anagen is prolonged, and telogen is shortened, increased hair growth results.
Two more clinical trials and seven published studies have confirmed the dramatic hair-growth effects of procyanidins from apples. • Total number of hairs: Significantly increased • Total number of terminal hairs: Significantly greater • Increase in hair diameter: 79 percent positive • Ratio of thicker (terminal) hairs: Significantly higher • Hair follicle activation: Intensive Most exciting: Japanese researchers released a 2005 study in which procyanidin therapy proved successful in regrowing hair for subjects MECHANISM OF ACTION with male pattern baldness. Published in the Journal of Cosmetic Dermatology, it confirmed earlier studies that showed clear improvement in number and density of hairs. Extending the trial to 12 months proved that long-term procyanidin therapy was even more successful. Copper peptides. These amino acid groups have two main properties: 1) as potently protective anti-inflammatory agents that limit oxidative
damage after tissue injury, and 2) as tissue remodeling agents that remove damaged protein and scar tissue, and activate their replacement with normal tissue. Studies conducted at universities and research institutes found that copper peptides improved hair transplant success, increased hair follicle size, stimulated hair growth, and reduced hair loss.
When scientists at the University of San Francisco Wound Center applied a synthetic copper peptide to the severe wounds of several patients, wounds healed 30 percent faster, and significant stimulation of follicular cells occurred. One tripeptide complex grew hair in the wound area.
The startling discovery led them to try the same copper peptide complex on a female patient who had suffered 90 percent alopecia (hair loss) for years. After six months, she recovered almost all of her hair. Dr. Loren Pickart, a leading authority on copper peptide technology, analogizes the activity to a protein injection for the scalp. Subsequent tests were conducted with chemotherapy and hair transplant patients, with great success in stimulating stronger hair follicles.
MECHANISM OF ACTION Spin traps. Special compounds originally used to measure free-radical activity, spin traps also react to produce more stable complexes.
The most commonly used spin trap, one by which others are measured, is alpha-phenyl-N-tert butyl nitrone (PBN). Studies conducted over 10 years have tested PBN and other spin traps, discovering they exert powerful free-radical-quenching abilities in living systems, and could treat a variety of conditions, protecting against tissue damage, complementing such antioxidants as vitamins C and E.
Spin traps modulate NF kappa-B-regulated cytokines and inducible nitric oxide synthases that are implicated in pro-inflammatory diseases. One method for ameliorating specific cellular dysfunction, such as treating hair loss and stimulating hair growth, is to administer a nitroso or nitrone spin trap to affected tissue. These agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps possess properties that ameliorate cellular dysfunction, in part due to high-energy oxygen and hydroxyl free radicals. PBN can be administered against alopecia to stimulate hair growth.
Depending on type of hair loss, the stimulation of growth can be achieved by daily topical application. The effects of spin traps extend to increasing rate of growth, diameter of hair, and follicular neogenesis, including inhibition of further hair loss. Ketoconazole. Topical ketoconazole has an anti-dihydrotestosterone-binding effect in the scalp, as well as other anti-hair-loss effects.
MECHANISM OF ACTION One theory of ketoconazole's anti-alopecia activity is its ability to remove sebum, the fatty substance that accumulates around hair follicles. Another possible method of action is its antifungal properties, highly significant for combating hair loss. It reduces scalp irritation caused by fungal colonization or infection, which is crucial to quelling the inflammatory process that occurs in male pattern balding.
The role of androgens, specifically DHT, is to choke hair follicles by inhibiting an enzyme called adenylate cyclase. When DHT concentration is high, researchers observe that thick, coarse, terminal hairs whither into thin, limp, vellus hairs (peach fuzz).
At a 2001 dermatology meeting in Washington, scientists presented good news from a study of 1% ketoconazole shampoo. In the double-blind study, 100 male volunteers with mild to moderate dandruff and somewhat oily scalp used either a 1% ketoconazole or a 1% zinc pyrithione shampoo, two or three times a week for six months. Analysis showed that hair diameter gradually increased with ketoconazole (8.5 percent), whereas diameter decreased with zinc pyrithione (-2.3 percent). The sebum excretion rate was reduced successfully with ketoconazole (-6.5 percent) while it increased with zinc pyrithione (8.2 percent). The total number of hairs shed was reduced by 16.5 percent with ketoconazole, but only by six percent with zinc pyrithione. These results reinforced a previous study of prescription 2% ketoconazole, in which it was shown to yield an increase in hair shaft diameter similar to that achieved by a group using 2% minoxidil with a non-medicated shampoo. MECHANISM OF ACTION Rooibos. Afrikaans for "red bush," this hardy shrub indigenous to South Africa is an exciting new botanical ingredient with potent antioxidant and
anti-inflammatory properties well documented in medical literature. In alternative medicine, rooibos is prescribed for nervous tension, allergies, and digestive problems. Results from study also showed a significant improvement in hair growth. Trials at an independent laboratory in France studied the effects of rooibos administered through a hair lotion to healthy persons suffering from hair loss. The 90-day trial compared rooibos with a placebo. Results showed significant increase in hair growth using the lotion containing rooibos. An increase was observed in 89 percent of volunteers, with no undesirable irritation, allergy, or other reactions. Sixty-seven percent of participants rated their hair loss as little or none; 78 percent reported low to medium improvement; 45 percent saw low to medium regrowth of hair; and 63 percent said hair was smoother and shinier. Conclusion: The study showed most of the volunteers enjoyed remarkable increase in hair growth and decrease in hair loss.
MSM. Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat,
fish, legumes, nuts, eggs, and vegetables, especially onions. Sulphur has become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane (MSM).
American chemist Robert Herschler began studying MSM in 1955. Dr. Stanley Jacob, with Oregon Health Sciences University, found that simple MECHANISM OF ACTION marine algae and plankton convert inorganic sulphur into organic compounds known as dimethylsulfonium salts. They get transformed into dimethyl sulfide (DMS), released into the atmosphere, and converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM to be absorbed by plants and become food for animals. When taken as a dietary supplement, MSM — a white, crystalline, odorless, nearly tasteless powder — conveys the same health benefits as DMSO, without the side effects like bad breath, itchy skin, nasal congestion, and shortness of breath. MSM helps to develop stronger hair by normalizing body functions. Sulfur from MSM is required for healthy collagen and keratin, essential to hair, skin, and nails. MSM also contributes antioxidant benefits that can disrupt the damaging reactions of lipid peroxidation in cell membranes. MSM has been used widely as a dietary supplement without reports of allergy or intolerance. There are no known contraindications. Caffeine 4%. Active caffeine helps to regulate the effects of testosterone. Male pattern baldness is known to occur in individuals with
sensitivity to testosterone, causing damage to hair follicles that leads to baldness. Caffeine, a xanthine alkaloid, acts as a central nervous system stimulant in humans, warding off drowsiness and restoring alertness. A study at the University of Jena in Germany used hair samples from the scalps of young men in the first stages of hormone-related hair loss. The study tested hair organ cultures with four compounds: 1) a nutrient-based solution, 2) a testosterone solution, 3) a caffeine solution, and 4) a mixture of caffeine and testosterone. MECHANISM OF ACTION Solutions containing the caffeine nutrient helped to stave off hair loss and encourage new growth, while those that relied just on testosterone led to increased hair loss. The most impressive result was the testosterone and caffeine mixture, which helped to prevent further hair loss.
These results demonstrated that by using the caffeine treatment, average growth was increased by 46 percent, and the life cycle of hair was extended by 37 percent, compared to controls.
Carnitine tartrate. L-carnitine, a vitamin-like nutrient, occurs naturally in the human body, and works to turn fat into energy. Active energy
metabolism is a prerequisite for growth of strong healthy hair. In biological systems, ATP acts as the universal currency of energy. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate.
Statistical evaluation has demonstrated a significant increase in ATP equivalents in human hair roots from plucked hair follicles treated with carnitine tartrate, suggesting it as an ideal ingredient for hair-care formulations, providing energy with which to produce strong hairs. These effects were absent in a placebo group, underlining the stimulating activity of carnitine tartrate.
The outstanding bio-activity of carnitine tartrate was further demonstrated in another study, assessing the effects after a single application of a shampoo supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased.
Amino acids. Ornitine, taurine, and cysteine are the building blocks of protein, which creates hair. They assemble in a certain sequence
MECHANISM OF ACTION to form keratin, the immensely strong protein that makes up 88 percent of hair. Amino acids have to be replaced constantly, as damage accumulates over time. We can replace these lost amino acids in hair, where they contribute tensile strength. But if follicles are deprived of essential blood flow, nutrients, minerals, or vitamins, they cannot produce hair properly. Extremities like the vertex of the scalp are the most difficult places in which to maintain blood flow. Keratin protein is comprised of polypeptide chains that break down into individual amino acids, joined together by peptide bonds between the carbon atom of one and the nitrogen atom of the next. Amino acids arranged in specific sequences form specific proteins, such as keratin, insulin, or collagen. "Alpha helix" describes the polypeptide chain that forms human hair protein. Its structure is a coil with approximately 3.6 amino acids per turn.
L-arginine is a semi-essential amino acid synthesized from L-ornithine. Arginine plus ornithine support protein synthesis because they are both involved in the transport and storage of nitrogen. Taurine corrects a damaging rigidification of the connective sheath surrounding piloseba- ceous units, especially those affected by androgenic hair loss. The amino acid L-cysteine speeds hair growth and increases hair shaft diameter, resulting in fuller hair. L-cysteine facilitates longer hair growth, beyond what is genetically programmed, and provides potent antioxidant protection. Users have reported hair regrowth.
MECHANISM OF ACTION Emu Oil. Dromaius novaehollandiae, the emu, is a flightless bird of the group ratites, which includes the ostrich and kiwi. Modern Australians,
who export emu oil, learned about its valuable qualities long ago from the Aborigines. In the United States, a growing network of research labs now study the benefits of emu oil, believed to include skin hydration, rejuvenation, and joint relief. Rendered from a thick pad of fat on the bird's back, nature may have provided the oil as protection from the extreme temperatures of its Australian homeland.
The natural nutrient penetrates deeply to hydrate human hair and skin. Boston University dermatology professor Michael Hollick studied emu oil and hair growth, and found a 20-percent increase in growth when skin received emu oil, compared to corn oil. Hair follicles became more robust, and skin thickened remarkably. Also, more than 80 percent of sleeping hair follicles woke up and began growing again.
Some reasons that topically applied emu oil seems to stimulate hair growth are its properties as an anti-inflammatory agent, 5-alpha-reductase inhibitor, and bacteriostat. These properties help Revita to keep hair nourished, so users retain more of it longer.
Biotin. A member of the B vitamin family and major component of natural hair manufacturing, biotin is essential to grow new hair, and it plays
MECHANISM OF ACTION a major role in the health of skin and nails. The beneficial effects of biotin derive from its ability to improve metabolism of scalp oils. When absorbed by the scalp, biotin may work to promote hair growth by penetrating the hair shaft, making it expand and thicken the hair cuticle.
Biotin works in cell growth, fatty acid production, and metabolism of fats and amino acids. It plays a role in the Krebs cycle, by which energy is released from food, and is sufficiently important to hair that dermatologists prescribe it to patients as part of medical treatment for hair loss.
After applying Revita with a gentle massage, leave it on the scalp for one or two minutes before rinsing. Repeat and leave it on the scalp for
DIRECTIONS FOR USE three to five minutes. If desired, follow with a high quality conditioner. For optimal results, use Revita at least five times per week.
This formula is contraindicated for individuals with a history of sensitivity reactions to any of its components. It should be discontinued
if hypersensitivity is noted.
Q: Is Revita safe?
A: Revita contains compounds that not only are safe for topical use but also enhance overall skin health dramatically. Other active ingredients, such as ketoconazole, have been tested and shown safe in clinical studies.
Q: Can I use hair sprays, mousses, gels, etc.?
A: Hair sprays, mousses, and gels can clog hair follicles, so are not recommended, but can be used safely with Revita, which helps to clear them.
Q: Can I have my hair colored or permed while using Revita?
A: While no evidence suggests that coloring or perming hair leads to hair loss, it is generally not recommended. Those experiencing hair loss should avoid applying unnecessary chemicals to the scalp, but they should not interfere with Revita.
Q: What is an SLS/SLES-free formula?
A: SLS (sodium lauryl sulfate) and SLES (sodium laureth sulfate), commonly used low-cost detergents, are linked to skin irritation, skin drying, and hair loss. Revita is free of SLS and SLES, so the formula does not irritate scalp. Instead, it preserves follicle health.
Q: Can I blow dry my hair after using Revita?
A: Extreme heat damages the protein in hair, leaving it fragile. Use a cool or warm setting if blowing hair dry after treating with Revita.
Q: Who is a good candidate for Revita?
A: The ideal candidate is someone in the beginning stages of hair loss, since it is easier to prevent baldness than to regrow hair. Anyone concerned about hair loss should start using Revita immediately.
Q: What results should I expect with Revita?
A: Keep realistic expectations. Depending on duration and severity of hair loss, it could take several weeks or months to see new hair. Do not be alarmed if there is increased hair loss in the first two weeks of treatment. Old hairs get pushed out as follicles start to grow new strands.
Q: Does Revita have any systemic side effects?
A: No. Used as directed, Revita's active ingredients have a long, well documented record of safety. Some are used both orally and topically.
Q: Does Revita work for women?
A: Yes. Hair loss in women is surprisingly similar to that in men. Fortunately for women, estrogen protects hair follicles from many of the destructive effects of dihydrotestosterone (DHT). Hair thinning may fluctuate with the levels of estrogen and DHT. Revita can help protect hair follicles from DHT, resulting in thicker, fuller, healthier hair.
Q: I am using other topical treatments. Can I use Revita at the same time?
A: Yes. Revita does not react with other topical treatments. You can use it safely. For best results, we recommend adding Spectral.RS® leave-in treatment for thinning hair, Spectral.DNC® for more advanced hair loss, and Spectral.DNC-L® in the most advanced stages of baldness.
Q: Do I need to use Revita for a long time?
A: After achieving desired results, continue to use Revita as your regular shampoo to maintain revitalized hair and healthy scalp.
Q: Is stress a factor in hair loss?
A: Yes, under physical or emotional stress, the immune system can produce antibodies that attack hair follicles, resulting in bald patches (diffuse loss). But stress-induced hair loss responds well to Revita, which should be used as your regular shampoo to keep the scalp healthy.
B6 UltimateProfessional Balance Charger/Discharger SkyRC Technology Co., Ltd. 2010 TABLE OF CONTENTSIntroduction.02Special features.05Warning and safety notes.09Program flow chart.14Lithium polymer balance charge program connection diagram.16Initial parameter setup (users set up).18Lithium battery (LiIon/LiPo/LiFe) program.21Charging lithium battery in the charge mode.22Charging lithium battery in the balance mode.23Charging lithium battery in the fast charge mode.24Charging lithium battery in the s